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2’-FL helps support the developing immune system in the gut and beyond1–7

Human milk oligosaccharides (HMOs) are complex carbohydrates which form the 3rd most abundant solid component in breast milk after lactose and lipids8

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Read more about the past, present and future of 2’-FL research

The most abundant HMO in most mothers’ milk is 2’-fucosyllactose (2’-FL), a trisaccharide consisting of glucose, galactose and fucose.1

Approximately 80% of women can produce and secrete 2’-FL in their breast milk,9 which has proven benefits on the gut and systemic immune responses.1–7

Less complex carbohydrates, such as the prebiotic sugars galacto-oligosaccharides (GOS) and fructo-oligosaccharides (FOS), have also demonstrated benefits on the gut, however GOS and FOS do not appear to have a direct role supporting the systemic immune system.4

How does 2’-FL support immune development in the gut and beyond?

Infants fed standard formula with 2’-FL*, compared with standard formula without 2’-FL*, have:


66% fewer parent reports of respiratory infections (p<0.05)1


Significantly lower levels of multiple inflammatory cytokines (p≤0.05), which were comparable to levels of breastfed infants2


Significantly fewer (0% vs 5%) parent reports of eczema (p<0.05)3

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See how formula-fed infants with CMA can benefit from 2’-FL    

IMPORTANT NOTICE: Breastfeeding is best for infants and is recommended for as long as possible during infancy.

*The 2'-FL (2'-fucosyllactose) used in this formula is biosynthesised and structurally identical to the human milk oligosaccharide (HMO) 2'-FL, found in most mothers' breast milk1.
Studies conducted in healthy-term infants fed standard Similac formula with 2’-FL (not Alimentum or EleCare), compared to control formula without 2’-FL.

2’-FL: 2’-fucosyllactose; FOS: fructo-oligosaccharides; GOS: galacto-oligosaccharides; HMO: human milk oligosaccharide.